Uncaria
Uncaria
Uncaria 是一种传统上用于多种草药医学实践的植物，尤其在东南亚和南美洲。Uncaria 的具体传统用途尚未得到充分记录；然而，它因其据称具有的医用特性而被使用。科学证据表明，Uncaria 中的某些化合物，如 Epi-A，具有强大的抗疟疾活性且毒性极低。此外，研究已在 Uncaria gambir 中鉴定出 strictosamide 和 3α-dihydrocadambine，它们分别表现出显著的磷酸酶抑制和血管舒张作用。另一种 Uncaria，即 rhynchophylla，被证明具有神经保护特性，通过降低氧化应激并调节 C. elegans 和 PC12 细胞中的相关基因表达来实现。尚未记录关于 Uncaria 的主要安全问题；目前科学证据有限。没有报告与使用 Uncaria 有关的药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- Epi-A在体外和体内均表现出强大的抗疟疾活性且无明显毒性。
- 研究在乌尼卡尔·甘比尔（Uncaria gambir）中鉴定了strictosamide和3α-二氢香豆宁，分别显示出对CDC25B磷酸酶的显著抑制作用和舒张血管活性。
- Imoviral® 补充剂导致早期短暂的TNF-α和IL-1β上调，与其他免疫基因相比，其他组别中的变化有限。
- 来自 Uncaria rhynchophylla 的 URA 在秀丽隐杆线虫和 PC12 细胞中均通过减少氧化应激和调节相关基因表达显示出神经保护效应。
Frequently asked questions
What is Uncaria?
Uncaria (Uncaria) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Uncaria?
4 sourced findings are recorded for Uncaria; the strongest carries evidence grade D. For example: Epi-A在体外和体内均表现出强大的抗疟疾活性且无明显毒性。
How strong is the evidence for Uncaria?
The strongest finding for Uncaria carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Uncaria safe? What are the side effects?
No major safety issues are recorded for Uncaria in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Uncaria interact with medications?
No drug interactions are recorded for Uncaria in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Uncaria?
Uncaria is also known as: Ункария.
Is Uncaria a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Evaluation of Imoviral® effects on early immune response in Sparus aurata challenged with Vibrio anguillarum. literature abstract metadata
- T2 Chemical components from Uncaria gambir (W.Hunter) Roxb. and their preliminary bioactivities in CDC25B phosphatase inhibition and vasodilatory activity. literature abstract metadata
- T2 Neuroprotective effects of Uncaria rhynchophylla alkaloid extracts against amyloid-β toxicity via regulation of oxidative stress pathways. literature abstract metadata
- T2 Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10. literature abstract metadata