Cat's Claw
Uncaria tomentosa
Uncaria tomentosa, commonly known as cat's claw, is a traditional medicine used in South American folk remedies. While its specific uses are not extensively documented, it has been traditionally employed for various conditions such as digestive issues and immune support. Scientific evidence suggests potential benefits, including reduced progression of aortic plaque and improved vascular histology in rabbits fed a high-fat diet, possibly through mechanisms involving ox-LDL uptake inhibition and reduced inflammatory responses. Uncaria tomentosa extracts also showed selective cytotoxicity against certain cancer cell lines, with aqueous bark and pentacyclic oxindole alkaloid-rich extracts being particularly promising. Quinovic acid was noted for enhancing KHYG-1 cell cytotoxicity by modulating the Ras/MAPK signaling pathway and increasing interferon-gamma expression. No major safety issues or drug interactions have been recorded, but further research is needed to fully understand its therapeutic potential and safety profile.
- 最佳证据
- A
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同,请查阅所引来源。
科学怎么说
- Imoviral® 补充剂导致早期短暂的TNF-α和IL-1β上调,与其他免疫基因相比,其他组别中的变化有限。
- Rhy 减少了主动脉斑块的进展,并通过抑制氧化低密度脂蛋白(ox-LDL)摄取和减少炎症反应改善了高脂饮食喂养兔的血管组织学。
- 从 Uncaria tomentosa 提取物显示出对某些癌细胞系的选择性细胞毒性,其中粗水提取物和富含五环氧化吲哚生物碱的提取物最具前景。
- 奎尼酸增强了KHYG-1细胞的细胞毒性,通过调节Ras/MAPK信号传导途径并增加干扰素-γ的表达。
Frequently asked questions
What is Cat's Claw?
Cat's Claw (Uncaria tomentosa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Cat's Claw?
4 sourced findings are recorded for Cat's Claw; the strongest carries evidence grade A. For example: Imoviral® 补充剂导致早期短暂的TNF-α和IL-1β上调,与其他免疫基因相比,其他组别中的变化有限。
How strong is the evidence for Cat's Claw?
The strongest finding for Cat's Claw carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Cat's Claw safe? What are the side effects?
No major safety issues are recorded for Cat's Claw in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Cat's Claw interact with medications?
No drug interactions are recorded for Cat's Claw in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Cat's Claw?
Cat's Claw is also known as: Ункария опушённая, Liane du Pérou.
Is Cat's Claw a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Cytotoxic effect of different Uncaria tomentosa (cat's claw) extracts, fractions on normal and cancer cells: a systematic review. literature abstract metadata
- T2 Rhynchophylline alleviates early atherosclerosis by attenuating oxidized low-density lipoprotein-induced foam cell formation and endothelial dysfunction. literature abstract metadata
- T2 Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. literature abstract metadata
- T2 Evaluation of Imoviral® effects on early immune response in Sparus aurata challenged with Vibrio anguillarum. literature abstract metadata