Cat's Claw

Uncaria tomentosa, commonly known as cat's claw, originates from traditional medicine practices in South America. It has been traditionally used for a variety of ailments including arthritis and digestive disorders, though specific uses vary among different indigenous cultures. Scientific evidence on Uncaria tomentosa is limited but shows potential benefits. For instance, Imoviral® supplementation led to early transient upregulation of TNF-α and IL-1β in some studies, suggesting immune system modulation. Additionally, Rhy reduced aortic plaque progression and improved vascular histology in rabbits fed a high-fat diet by inhibiting ox-LDL uptake and reducing inflammatory responses. Uncaria tomentosa extracts also demonstrated selective cytotoxicity against certain cancer cell lines, with the most promising results coming from crude aqueous bark and pentacyclic oxindole alkaloid-rich extracts. Quinovic acid further enhanced this effect by modulating the Ras/MAPK signaling pathway and increasing interferon-gamma expression in KHYG-1 cells. Safety data indicates no major issues have been recorded, but comprehensive long-term studies are still needed to fully assess potential risks. There are currently no reported drug interactions with Uncaria tomentosa, though further research is warranted given its diverse biological activities.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.