Abuta grandifolia
Abuta grandifolia
Abuta grandifolia, a plant native to Central America, has not been extensively documented in traditional medicine. Scientific studies have primarily focused on its biological properties rather than therapeutic uses. Research indicates that various parts of the plant, including fruit, leaves, and seeds, are commonly consumed. There is preliminary evidence suggesting potential renoprotective effects from Abuta grandifolia, which could help prevent kidney function reductions due to ischemia. Additionally, krukovine, a compound derived from this plant, has shown antiproliferative activity in oxaliplatin-resistant pancreatic cancer cells and organoids, with enhanced efficacy when combined with oxaliplatin. It also inhibits the growth and proliferation of KRAS-mutated lung cancer cells by downregulating RAF-ERK and AKT pathways. No major safety concerns or recorded drug interactions have been identified to date.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The review found a predominance of consumption of fruit, leaves, and seeds, representing 85.8% of total parts used.
- The study suggests that Abuta grandifolia may promote renoprotection, preventing some kidney function reductions due to ischemia.
- Krukovine, from Abuta grandifolia, inhibits growth and proliferation of KRAS-mutated lung cancer cells by downregulating RAF-ERK and AKT pathways.
- KV shows antiproliferative effects in oxaliplatin-resistant pancreatic cancer cells and organoids, with enhanced inhibition when combined with oxaliplatin.
Frequently asked questions
What is Abuta grandifolia?
Abuta grandifolia (Abuta grandifolia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Abuta grandifolia?
4 sourced findings are recorded for Abuta grandifolia; the strongest carries evidence grade A. For example: The review found a predominance of consumption of fruit, leaves, and seeds, representing 85.8% of total parts used.
How strong is the evidence for Abuta grandifolia?
The strongest finding for Abuta grandifolia carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Abuta grandifolia safe? What are the side effects?
No major safety issues are recorded for Abuta grandifolia in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Abuta grandifolia interact with medications?
No drug interactions are recorded for Abuta grandifolia in our sources. This does not rule them out — check with a pharmacist.
Is Abuta grandifolia a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway. literature abstract metadata
- T2 Antiproliferative Activity of Krukovine by Regulating Transmembrane Protein 139 (TMEM139) in Oxaliplatin-Resistant Pancreatic Cancer Cells. literature abstract metadata
- T2 Amazonia Phytotherapy Reduces Ischemia and Reperfusion Injury in the Kidneys. literature abstract metadata
- T2 Patterns of use of wild food plants by Brazilian local communities: systematic review and meta-analysis. literature abstract metadata