Aconitum coreanum
Aconitum coreanum
Aconitum coreanum, a plant traditionally used in East Asian medicine, particularly in Korea and China, has not been extensively documented for specific traditional uses. Scientific studies have shown that Aconitum coreanum plays a role in the biosynthesis of diterpenoids such as tripterifordin, which may contribute to its biological activities. Research indicates potential neuroprotective effects, with evidence suggesting it can reduce infarct size and neuronal apoptosis in models of cerebral ischemic stroke, possibly through modulation of pathways like PI3K/Akt, KEAP1/NRF2, AMPK/mTOR/ULK1. Hypaconitine from Aconitum coreanum has also demonstrated significant toxicity and antifeedant activity against Mythimna separata larvae. No major safety concerns or recorded drug interactions have been identified for this plant, but its use should be approached with caution due to the presence of toxic components.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identifies key enzymes enabling the biosynthesis of diverse diterpenoids in Aconitum, including tripterifordin.
- Aconitum coreanum and its processed forms protected against stroke in gerbils by affecting the PI3K/Akt and KEAP1/NRF2 pathways.
- Aconitum coreanum reduces infarct size and neuronal apoptosis, and inhibits autophagy through the AMPK/mTOR/ULK1 pathway in cerebral ischemic stroke rats.
- Hypaconitine from Aconitum coreanum showed significant toxicity and antifeedant activity against Mythimna separata larvae through multiple mechanisms.
Frequently asked questions
What is Aconitum coreanum?
Aconitum coreanum (Aconitum coreanum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Aconitum coreanum?
4 sourced findings are recorded for Aconitum coreanum; the strongest carries evidence grade D. For example: The study identifies key enzymes enabling the biosynthesis of diverse diterpenoids in Aconitum, including tripterifordin.
How strong is the evidence for Aconitum coreanum?
The strongest finding for Aconitum coreanum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Aconitum coreanum safe? What are the side effects?
No major safety issues are recorded for Aconitum coreanum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Aconitum coreanum interact with medications?
No drug interactions are recorded for Aconitum coreanum in our sources. This does not rule them out — check with a pharmacist.
Is Aconitum coreanum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Aconitum coreanum and processed products on its base prevent stroke via the PI3K/Akt and KEAP1/NRF2 in the in vivo study. literature abstract metadata
- T2 Divergent multifunctional P450s-empowered biosynthesis of bioactive tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution. literature abstract metadata
- T2 Toxicity of Hypaconitine from Aconitum coreanum (H. Lév.) Rapaics Against the Oriental Armyworm, Mythimna separata (Walker). literature abstract metadata
- T2 Aconitum coreanum (H.Lév l.) Rapaics exerts neuroprotective effects on cerebral ischemic stroke by inhibiting autophagy through the AMPK/mTOR/ULK1 pathway. literature abstract metadata