White sapote
Casimiroa edulis
Casimiroa edulis, also known as ice-apple or false-memecysteine, is a traditional plant native to Central America and Mexico. While its use in traditional medicine has not been extensively documented, studies have shown potential benefits. Scientific evidence suggests that treatments with Casimiroa edulis can improve sperm quality and restore testicular enzyme activity in diabetic male rats, indicating possible reproductive health applications. Additionally, hexane and dichloromethane extracts from the leaves of this plant induce vasorelaxation through nitric oxide release and calcium channel blockade, which could have cardiovascular implications. Casedulones from Casimiroa edulis also suppress MMP9 expression via inhibition of the JAK/STAT3 pathway and TNFα-dependent pathways, suggesting anti-inflammatory properties. A leaf extract encapsulated in biodegradable nanoparticles demonstrated antioxidant activity; however, further efficacy studies are required to confirm these findings. No major safety concerns or recorded drug interactions have been identified for Casimiroa edulis thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Casimiroa edulis treatment improved sperm quality and restored testicular enzyme activity in diabetic male rats.
- Hexane and dichloromethane extracts from Casimiroa edulis leaves induced vasorelaxation through NO release and calcium channel blockade in rats.
- Casedulones from Casimiroa edulis suppress MMP9 expression via inhibition of the JAK/STAT3 pathway and TNFα-dependent pathways.
- A leaf extract of Casimiroa edulis was encapsulated in biodegradable nanoparticles showing antioxidant activity, but efficacy studies are needed.
Frequently asked questions
What is White sapote?
White sapote (Casimiroa edulis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about White sapote?
4 sourced findings are recorded for White sapote; the strongest carries evidence grade D. For example: Casimiroa edulis treatment improved sperm quality and restored testicular enzyme activity in diabetic male rats.
How strong is the evidence for White sapote?
The strongest finding for White sapote carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is White sapote safe? What are the side effects?
No major safety issues are recorded for White sapote in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does White sapote interact with medications?
No drug interactions are recorded for White sapote in our sources. This does not rule them out — check with a pharmacist.
What are the common names of White sapote?
White sapote is also known as: Белая сапота, Sapote blanche.
Is White sapote a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Methoxylated Flavones from Casimiroa edulis La Llave Suppress MMP9 Expression via Inhibition of the JAK/STAT3 Pathway and TNFα-Dependent Pathways. literature abstract metadata
- T2 Vasorelaxant and Antihypertensive Effects of Extracts from the Leaves of Casimiroa edulis La Llave (Rutaceae) by NO Release and Calcium Channel Blockade. literature abstract metadata
- T2 Casimiroa edulis extract modulates testosterone levels, testicular enzymes and spermatogenesis disorders in streptozotocin-induced diabetic male rats. literature abstract metadata
- T2 Casimiroa edulis Leaf Extract-Loaded PLGA Nanoparticles: Untargeted Phytochemical Profiling and Wound-Healing-Oriented Antioxidant/Occlusive Characterization. literature abstract metadata