Coix millet
Coix lacryma-jobi var. ma-yuen
Coix lacryma-jobi var. ma-yuen, also known as Job's tears or Coix seed, originates from traditional Chinese medicine and has a long history of use in East Asian cultures. Traditionally, it is believed to have various health benefits such as improving liver function, enhancing spleen function, regulating intestinal microbiota, and possessing anti-inflammatory properties. However, there are no specific recorded uses for this plant in modern traditional practices. Scientific evidence suggests that Coix seed may exhibit multiple pharmacological effects, including hypoglycemic actions, improvement of liver function, anti-tumor activity, and regulation of the intestinal microbiome. Additionally, modified formulations of YGJT (a traditional Chinese medicine) have shown significant improvements in objective response rate, disease control rate, and Karnofsky Performance Status in lung cancer patients. While studies indicate potential mechanisms involving ferroptosis in gastric cancer cells, further research is needed to confirm these findings. Safety-wise, no major issues have been recorded for Coix seed. There are currently no reported drug interactions associated with its use. However, as with any herbal supplement, individuals should consult healthcare providers before incorporating it into their regimen, especially those undergoing treatment or taking other medications.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- GWAS have identified several loci associated with serum uric acid levels, while TCM shows multi-component effects on uric acid homeostasis.
- The study reviews that Coix seed exhibits multiple pharmacological effects including hypoglycemia, liver function improvement, anti-tumor activity, intestinal microbiota regulation, spleen function enhancement, and anti-inflammation.
- The study aims to examine the efficacy and safety of modified Saengmaeksan in treating hypertensive patients over 12 weeks.
- Modified YGJT significantly improved objective response rate, disease control rate, and Karnofsky Performance Status in lung cancer patients.
- The study suggests that traditional Chinese medicine formulations may trigger ferroptosis in gastric cancer cells, but underlying mechanisms remain unclear.
- Fermentation of adlay bran with Lactiplantibacillus plantarum enhanced its anti-melanogenic and antioxidant activities.
Frequently asked questions
What is Coix millet?
Coix millet (Coix lacryma-jobi var. ma-yuen) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Coix millet?
6 sourced findings are recorded for Coix millet; the strongest carries evidence grade A. For example: GWAS have identified several loci associated with serum uric acid levels, while TCM shows multi-component effects on uric acid homeostasis.
How strong is the evidence for Coix millet?
The strongest finding for Coix millet carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Coix millet safe? What are the side effects?
No major safety issues are recorded for Coix millet in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Coix millet interact with medications?
No drug interactions are recorded for Coix millet in our sources. This does not rule them out — check with a pharmacist.
Is Coix millet a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Research on Coix seed as a food and medicinal resource, it's chemical components and their pharmacological activities: A review. literature abstract metadata
- T2 Safety and effectiveness of an herbal decoction (modified Saengmaeksan) in hypertensive patients: Protocol for a real-world prospective observational study. literature abstract metadata
- T2 Therapeutic potential of modified Yukgunja-tang (Liujunzi Decoction, Rikkunshito) as an adjuvant treatment for lung cancer: a systematic review and meta-analysis. literature abstract metadata
- T2 Upcycling of Adlay Bran via Lactobacillus Fermentation Enhances Anti-Melanogenic and Antioxidant Activities through MITF/Tyrosinase Pathway Modulation. literature abstract metadata
- T2 Pharmacological intervention of Chinese medicine via regulating ferroptosis in gastric cancer. literature abstract metadata
- T2 Genome-wide association studies and traditional Chinese medicine in hyperuricemia: current evidence and mechanistic insights. literature abstract metadata