Small corydalis
Corydalis ambigua
Corydalis ambigua is a plant traditionally used in some Asian medicinal practices, particularly in China. It has been noted for its potential anti-cancer properties, with studies showing that Corydalis ambigua can induce apoptosis and cell cycle arrest in colon cancer cells through the regulation of c-Myc expression. Additionally, research indicates that the flowering timing of this plant varies among populations due to differences in snowmelt times, which may affect seed production by potentially disrupting phenological synchrony with pollinators. The plant's active component, acetylcorynoline, has been studied for its pharmacokinetics and bioavailability using UPLC-MS/MS methods. L-threo-hypaconitine (l-THP) also exhibits potential as it inhibits the α4β2 nicotinic receptor response to nicotine in cultured cells. No major safety concerns or known drug interactions have been recorded for Corydalis ambigua, though further research is needed to fully understand its broader applications and effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- ACN from Corydalis ambigua induced apoptosis and cell cycle arrest in colon cancer cells by regulating c-Myc expression.
- Flowering timing of Corydalis ambigua varies among populations with different snowmelt times, affecting seed production due to potential phenological mismatch with pollinators.
- The study developed and validated an UPLC-MS/MS method to determine acetylcorynoline in mouse plasma, showing its pharmacokinetics and bioavailability.
- l-THP inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells.
Frequently asked questions
What is Small corydalis?
Small corydalis (Corydalis ambigua) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Small corydalis?
4 sourced findings are recorded for Small corydalis; the strongest carries evidence grade D. For example: ACN from Corydalis ambigua induced apoptosis and cell cycle arrest in colon cancer cells by regulating c-Myc expression.
How strong is the evidence for Small corydalis?
The strongest finding for Small corydalis carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Small corydalis safe? What are the side effects?
No major safety issues are recorded for Small corydalis in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Small corydalis interact with medications?
No drug interactions are recorded for Small corydalis in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Small corydalis?
Small corydalis is also known as: Хохлатка обманчивая.
Is Small corydalis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells. literature abstract metadata
- T2 Acetylcorynoline Induces Apoptosis and G2/M Phase Arrest through the c-Myc Signaling Pathway in Colon Cancer Cells. literature abstract metadata
- T2 Determination and Pharmacokinetics of Acetylcorynoline in Mouse Plasma by UPLC-MS/MS. literature abstract metadata
- T2 Site-specific variation in flowering phenology of a spring ephemeral plant and its implications for phenological mismatch with pollinators under climate change. literature abstract metadata