Bunge’s corydalis
Corydalis bungeana
Corydalis bungeana, a traditional medicine plant, is primarily used in East Asian herbal practices. While its specific uses are not well-documented, it has shown potential therapeutic effects in various studies. Scientific evidence suggests that Corydalis bungeana compounds may have benefits for polycystic ovary syndrome (PCOS) through interactions with estrogen receptor and SRC pathways. Additionally, AC (likely a compound from the plant) can reduce liver injury by inhibiting the TLR4/JNK/NF-κB pathway. Other studies indicate that corynoline, another compound, may inhibit glioblastoma cell proliferation and promote apoptosis via the STAT3/Bcl-2 signaling pathway and also inhibit osteosarcoma cell proliferation through Src/JNK signaling-mediated G2/M phase arrest and mitochondrial apoptosis. Safety concerns are currently minimal with no major issues recorded, and there is no reported evidence of drug interactions at this time.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- AC reduces liver injury by inhibiting the TLR4/JNK/NF-κB pathway in both in vivo and in vitro experiments.
- Corynoline inhibits osteosarcoma cell proliferation and promotes apoptosis viaSrc/JNK signaling-mediated G2/M phase arrest and mitochondrial apoptosis.
- The study identified potential therapeutic effects of Corydalis bungeana compounds on PCOS through interactions with ESR1 and SRC proteins.
- Corynoline inhibited glioblastoma cell proliferation and promoted apoptosis by regulating the STAT3/Bcl-2 signalling pathway.
Frequently asked questions
What is Bunge’s corydalis?
Bunge’s corydalis (Corydalis bungeana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bunge’s corydalis?
4 sourced findings are recorded for Bunge’s corydalis; the strongest carries evidence grade D. For example: AC reduces liver injury by inhibiting the TLR4/JNK/NF-κB pathway in both in vivo and in vitro experiments.
How strong is the evidence for Bunge’s corydalis?
The strongest finding for Bunge’s corydalis carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bunge’s corydalis safe? What are the side effects?
No major safety issues are recorded for Bunge’s corydalis in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bunge’s corydalis interact with medications?
No drug interactions are recorded for Bunge’s corydalis in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bunge’s corydalis?
Bunge’s corydalis is also known as: Хохлатка Бунге.
Is Bunge’s corydalis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Acetylcorynoline alleviates acute liver injury via inhibiting TLR4/JNK/NF-ĸB pathway Based on RNA-seq and molecular docking in vivo and in vitro. literature abstract metadata
- T2 Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis. literature abstract metadata
- T2 Corynoline promotes apoptosis and inhibits proliferation of glioblastoma via regulating the STAT3/Bcl-2 signalling pathway. literature abstract metadata
- T2 Therapeutic potential of Corydalis alkaloids in polycystic ovary syndrome: In silico and preliminary In vitro Insights into ESR1 and SRC-associated pathways. literature abstract metadata