Datura
Datura metel
Datura metel, also known as Jimsonweed, is a traditional plant used in Ayurvedic and folk medicine practices. Its specific uses are not well-documented in historical or contemporary traditions. Scientific evidence from experimental studies on rats suggests that combining D. metel with alcohol may have negative effects on the liver and prefrontal cortex, though these findings need further validation. Computational analyses indicate potential anti-cancer activity against EGFR inhibitors for lung cancer but require more empirical testing to confirm efficacy. No significant safety concerns or known drug interactions have been recorded for Datura metel; however, its use should be approached with caution due to the lack of comprehensive research and traditional documentation.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Combined D. metel and alcohol consumption negatively impacted the liver and prefrontal cortex in experimental rats.
- The study identified a glycoglycerolipid compound from Bacillus velezensis DM that showed dose-dependent reduction in melanin levels but did not significantly protect against UVB-induced damage or exhibit anti-allergic activity.
- Chemoinformatics analysis identified 10 potential drug-like alkaloids from Datura metel with tropane-class characteristics.
- This study identifies four phytochemicals from Datura metel as potentially effective EGFR inhibitors against lung cancer, based on computational analyses.
Frequently asked questions
What is Datura?
Datura (Datura metel) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Datura?
4 sourced findings are recorded for Datura; the strongest carries evidence grade D. For example: Combined D. metel and alcohol consumption negatively impacted the liver and prefrontal cortex in experimental rats.
How strong is the evidence for Datura?
The strongest finding for Datura carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Datura safe? What are the side effects?
No major safety issues are recorded for Datura in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Datura interact with medications?
No drug interactions are recorded for Datura in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Datura?
Datura is also known as: Дурман индийский, Datura métel, Métel.
Is Datura a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Identification of Datura metel phytochemicals as potential EGFR inhibitors in lung cancer. literature abstract metadata
- T2 Chemoinformatic analysis of alkaloids of Datura metel and Datura stramonium species: insights from chemical space and diversity analysis. literature abstract metadata
- T2 Metabolite profiling of Bacillus velezensis DM extract linked to the rhizosphere of Datura metel L. and dermatoprotective potential of an isolated glycoglycerolipid. literature abstract metadata
- T2 Datura metel and Alcohol Cocktail Potentiates Hepatic Encephalopathy by Exacerbating Impairment via the Hepato-Prefrontal Cortical Axis. literature abstract metadata