Matchbox Bean
Entada phaseoloides
Entada phaseoloides, a plant traditionally not extensively documented for medicinal use, has garnered scientific interest primarily due to its potential anti-inflammatory and immunomodulatory properties. Studies suggest that extracts from this plant may target ASCC2 to reduce chemokine expression and inhibit NF-κB activation, which can alleviate symptoms associated with allergic contact dermatitis (ACD). Additionally, Entada phaseoloides has shown promise in treating psoriasiform dermatitis by restoring keratinocyte homeostasis and suppressing neutrophil extracellular trap formation. In gout models, the plant extract PHA significantly suppressed NLRP3 inflammasome activation and attenuated inflammatory cascades both in vivo and in vitro, indicating its potential for managing gout symptoms. Four UGT73 family genes were identified and functionally characterized, highlighting their roles in flavonoid and triterpenoid glycosylation within the plant. Notably, no major safety concerns or recorded drug interactions have been identified to date, suggesting a generally safe profile for this plant extract.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- EA targets ASCC2 to reduce chemokine expression and inhibit NF-κB activation, alleviating ACD symptoms.
- EA treatment significantly alleviated IMQ-induced psoriasiform dermatitis by restoring keratinocyte homeostasis and suppressing neutrophil extracellular trap formation.
- Four UGT73 family genes were identified and functionally characterized in Entada phaseoloides, revealing their roles in flavonoid and triterpenoid glycosylation.
- PHA significantly suppressed NLRP3 inflammasome activation and attenuated inflammatory cascades in both in vivo and in vitro gout models.
Frequently asked questions
What is Matchbox Bean?
Matchbox Bean (Entada phaseoloides) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Matchbox Bean?
4 sourced findings are recorded for Matchbox Bean; the strongest carries evidence grade D. For example: EA targets ASCC2 to reduce chemokine expression and inhibit NF-κB activation, alleviating ACD symptoms.
How strong is the evidence for Matchbox Bean?
The strongest finding for Matchbox Bean carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Matchbox Bean safe? What are the side effects?
No major safety issues are recorded for Matchbox Bean in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Matchbox Bean interact with medications?
No drug interactions are recorded for Matchbox Bean in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Matchbox Bean?
Matchbox Bean is also known as: Haricotier géant.
Is Matchbox Bean a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Phaseoloidin, a homogentisic acid glucoside from Entada phaseoloides, suppresses gout inflammation via NLRP3 inflammasome. literature abstract metadata
- T2 Exploring the substrate promiscuity and functional residues of UGT73 family enzymes in Entada phaseoloides. literature abstract metadata
- T2 Entadamide A-β-D-glucopyranoside attenuates psoriatic dermatitis by restoring keratinocyte homeostasis and suppressing neutrophil extracellular traps. literature abstract metadata
- T2 Entagenic acid targets ASCC2 to ameliorate allergic contact dermatitis via repressing NF‑κB transactivation and chemokine expression. literature abstract metadata