Common spurge
Euphorbia pekinensis
Euphorbia pekinensis, a plant traditionally used minimally if at all in medicine, has shown promise in scientific research. Studies indicate that its component EP-GA hydrogel can inhibit tumor growth by 68.63% in H22 subcutaneous hepatocellular carcinoma (HCC) xenograft models, though the evidence is limited and further clinical trials are needed to confirm these findings. Additionally, two new compounds from Euphorbia pekinensis have shown potential activity against hepatocellular carcinoma with selective cytotoxicity, but more research is required to understand their full therapeutic implications. The plant's glycosphingolipids, such as hexosylceramide, can activate TRPA1 in enterochromaffin cells, leading to increased 5-HT release and potential intestinal dysfunction. Processing methods like vinegar, milk, or Terminalia chebula decoction have been shown to reduce toxicity by altering chemical structures or dissolving toxic components. No major safety issues or drug interactions have been recorded for Euphorbia pekinensis, but caution is advised given the limited data available.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that the EP-GA hydrogel inhibited tumor growth in H22 subcutaneous HCC xenograft models by 68.63% at 18.75 mg/kg.
- Two new compounds from Euphorbia pekinensis showed potential activity against hepatocellular carcinoma with selective cytotoxicity.
- This study reveals that vinegar, milk, and Terminalia chebula decoction processing can reduce toxicity in Euphorbia species by altering chemical structures or dissolving toxic components.
- Euphorbia pekinensis glycosphingolipids, including hexosylceramide, activate TRPA1 in enterochromaffin cells, leading to increased 5-HT release and intestinal toxicity.
Frequently asked questions
What is Common spurge?
Common spurge (Euphorbia pekinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Common spurge?
4 sourced findings are recorded for Common spurge; the strongest carries evidence grade D. For example: The study found that the EP-GA hydrogel inhibited tumor growth in H22 subcutaneous HCC xenograft models by 68.63% at 18.75 mg/kg.
How strong is the evidence for Common spurge?
The strongest finding for Common spurge carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Common spurge safe? What are the side effects?
No major safety issues are recorded for Common spurge in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Common spurge interact with medications?
No drug interactions are recorded for Common spurge in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Common spurge?
Common spurge is also known as: Молочай пекинский.
Is Common spurge a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 [Common detoxification mechanisms in processing of toxic medicinal herbs of the same genus: a case study of Euphorbia pekinensis, E. ebracteolata, and E. fischeriana]. literature abstract metadata
- T2 Euphorbia pekinensis glycosphingolipids disrupt gut motility and fluid balance via TRPA1 activation in enterochromaffin cells. literature abstract metadata
- T2 Injectable multi-component hydrogel as an inhibitor of choline kinase α achieved the treatment of malignant ascites by inhibiting PI3K/AKT/mTOR signaling pathway. literature abstract metadata
- T2 New terpenoids from Euphorbia pekinensis with potent and selective anti-hepatocellular carcinoma activity. literature abstract metadata