Hop
Humulus
Humulus, commonly known as hops, is a plant traditionally associated with brewing and its use in traditional medicine is not well-documented. Scientific studies have shown that Humulus lupulus extracts may offer renal protective effects by reducing markers of kidney damage such as urea, creatinine, uric acid levels, and increasing antioxidant activities like TAC, CAT, SOD, and GPx in animal models of nephrotoxicity. Additionally, Humulus scandens has demonstrated anti-cancer properties against non-small cell lung cancer through the suppression of the PI3K/Akt pathway, though these findings are currently limited to laboratory studies. As a feed additive, hops have shown mixed results with variable benefits and dose-dependent adverse effects in different animal species. No major safety concerns or drug interactions have been recorded for Humulus, but further research is needed to fully understand its potential applications and risks.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats.
- The study found variable interaction patterns between hop isolates against bacteria and chicken cells, with some additive and synergistic effects observed.
- Humulus scandens inhibited non-small cell lung cancer growth and metastasis by suppressing the PI3K/Akt pathway.
- Hops showed variable effects as feed additives in different animal species, with some benefits but also dose-dependent adverse impacts.
- Xanthohumol supplementation was associated with reduced secondary bile acids and increased IL-10, potentially improving symptoms in Crohn's disease patients.
- GWAS did not identify significant SNPs but found several candidate loci, including a wall-associated kinase, for Verticillium wilt resistance in hop.
Frequently asked questions
What is Hop?
Hop (Humulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Hop?
6 sourced findings are recorded for Hop; the strongest carries evidence grade B. For example: Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats.
How strong is the evidence for Hop?
The strongest finding for Hop carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Hop safe? What are the side effects?
No major safety issues are recorded for Hop in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Hop interact with medications?
No drug interactions are recorded for Hop in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Hop?
Hop is also known as: Хмель, Houblon.
Is Hop a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
- T2 The potential of Humulus scandens in delaying non-small cell lung cancer: Targeting the PI3K/Akt signaling pathway to inhibit tumor growth and metastasis. literature abstract metadata
- T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
- T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
- T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
- T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata