Petasites japonicus
Petasites japonicus
Petasites japonicus, commonly known as Japanese butterbur, is a plant traditionally used in East Asian medicine. While its specific traditional uses are not well-documented, it has shown promise in scientific research. Studies have indicated that Petasites japonicus leaves extract may alleviate symptoms of colitis and depression-like behaviors in mice through multiple mechanisms. Additionally, the extract PPJM (Petasites japonicus methanol extract) has been found to improve memory deficits and modulate cholinergic function and neuroinflammatory responses in mice. In a clinical trial with dogs, BSE (Butterbur root extract) administration extended overall survival but did not significantly impact progression-free survival for oral melanoma, showing safety when used as directed. The topical application of KP-1, derived from Petasites japonicus, has been shown to reduce UVB-induced skin damage by enhancing skin hydration and activating protective signaling pathways. No major safety issues or drug interactions have been recorded, but further research is needed to confirm these findings comprehensively.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Petasites japonicus leaves extract alleviated DSS-induced colitis and depression-like behaviors in mice through multiple mechanisms.
- PPJM pretreatment partially improved scopolamine-induced memory deficits and modulated cholinergic function and neuroinflammatory responses in mice.
- KP-1 reduced UVB-induced skin damage, including wrinkles and collagen degradation, while enhancing skin hydration and activating protective signaling pathways.
- BSE administration significantly extended overall survival but did not prolong progression-free survival in dogs with oral melanoma, and was safe to administer.
Frequently asked questions
What is Petasites japonicus?
Petasites japonicus (Petasites japonicus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Petasites japonicus?
4 sourced findings are recorded for Petasites japonicus; the strongest carries evidence grade D. For example: Petasites japonicus leaves extract alleviated DSS-induced colitis and depression-like behaviors in mice through multiple mechanisms.
How strong is the evidence for Petasites japonicus?
The strongest finding for Petasites japonicus carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Petasites japonicus safe? What are the side effects?
No major safety issues are recorded for Petasites japonicus in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Petasites japonicus interact with medications?
No drug interactions are recorded for Petasites japonicus in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Petasites japonicus?
Petasites japonicus is also known as: Белокопытник японский, Pétasite du Japon.
Is Petasites japonicus a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Anti-Photoaging Effects of a Standardized Hot Water Extract of Petasites japonicus Leaves in Ultraviolet B-Exposed Hairless Mice. literature abstract metadata
- T2 Clinical impact of butterbur shoot extract in dogs with oral melanoma: a combined phase 1 and 2 clinical trial. literature abstract metadata
- T2 Petasites japonicus Leaves Alleviate Depression in Dextran Sulfate Sodium-Induced Colitis Mice Through the BDNF/TrkB Pathway and Modulation of Inflammation. literature abstract metadata
- T2 Protective Effects of a Propolis-Petasites japonicus Mixture on Scopolamine-Induced Memory Impairment in Mice. literature abstract metadata