Angular Winter-cherry
Physalis angulata
Physalis angulata, commonly known as ground cherry or golden berry, is a plant traditionally used in various cultures but lacks specific traditional medicinal uses documented. Scientific evidence from a review of 239 medicinal plants across multiple ethnic groups in Indonesia highlighted methodological weaknesses, making definitive conclusions challenging. Laboratory studies have shown that water deficit can alter Physalis angulata's physiological responses, including changes in water status and gas exchange. Withanolides extracted from the plant demonstrated potent antimelanoma activity both in vitro and in vivo by activating the p53 pathway. Safety concerns are currently unreported, with no major issues recorded. Similarly, there is no evidence of significant drug interactions associated with Physalis angulata.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified withanolides from Physalis angulata that inhibit melanoma cell proliferation and tumor growth in mice by activating the p53 pathway.
- The review identified a shared core of 239 medicinal plant species across multiple ethnic groups in Indonesia, though quality assessment highlighted methodological weaknesses.
- PA interferes with cell cycle progression in human oral squamous carcinoma cells via DNA topoisomerase II/ATM/ATR/Chk signaling for G2/M phase arrest.
- Water deficit induced changes in Physalis angulata's water status, gas exchange, and accumulation of organic solutes, with varying responses depending on the duration of stress.
Frequently asked questions
What is Angular Winter-cherry?
Angular Winter-cherry (Physalis angulata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Angular Winter-cherry?
4 sourced findings are recorded for Angular Winter-cherry; the strongest carries evidence grade A. For example: The study identified withanolides from Physalis angulata that inhibit melanoma cell proliferation and tumor growth in mice by activating the p53 pathway.
How strong is the evidence for Angular Winter-cherry?
The strongest finding for Angular Winter-cherry carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Angular Winter-cherry safe? What are the side effects?
No major safety issues are recorded for Angular Winter-cherry in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Angular Winter-cherry interact with medications?
No drug interactions are recorded for Angular Winter-cherry in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Angular Winter-cherry?
Angular Winter-cherry is also known as: Coqueret.
Is Angular Winter-cherry a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Withanolides from Physalis angulata as Potent Antimelanoma Agents: Activation of the p53 Pathway In Vitro and In Vivo. literature abstract metadata
- T2 Physalin A interferes with cell cycle in human oral squamous carcinoma cells via DNA topoisomerase II/ATM/ATR/Chk signaling for G2/M phase arrest. literature abstract metadata
- T2 A systematic review of ethnobotanical study in Indonesia: diversity and cultural patterns of medicinal plant use. literature abstract metadata
- T2 Water deficit exposure: physiological and biochemical changes in Physalis angulata L. (Solanaceae). literature abstract metadata