Piper wallichii
Piper wallichii
Piper wallichii is a plant species rooted in traditional medicinal practices. It is traditionally utilized as a refrigerant and for the management of hypertension. Scientific evidence suggests potential therapeutic properties, as ethanol extracts have shown some ability to improve symptoms of ulcerative colitis in murine models by affecting inflammatory factors. Additionally, petroleum ether fractions have demonstrated potential antiaging effects in C. elegans, and the alkaloid wallichinine may influence drug efflux in certain cancer cells. Some compounds also show weak antibacterial activity. No major safety issues or notable drug interactions are currently recorded.
- Traditionally for
- hypertension · refrigerant
- Traditions
- traditional
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
Traditional use
- hypertension
- refrigerant
What the science says
- The ethanol extract of Piper wallichii improved symptoms of DSS-induced ulcerative colitis in mice by affecting inflammatory and immune factors.
- Piper wallichii petroleum ether fraction extended lifespan and improved healthspan in C. elegans by activating autophagy, showing potential for antiaging and anti-AD effects.
- Wallichinine enhances the effects of certain ABCB1 substrates on cancer cells without altering sensitivity to non-substrates, by blocking ABCB1's drug-efflux activity.
- Two new compounds were identified from Piper wallichii with weak antibacterial activity against certain pathogens.
Frequently asked questions
What is Piper wallichii?
Piper wallichii (Piper wallichii) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What is Piper wallichii traditionally used for?
Traditional sources record Piper wallichii for: hypertension, refrigerant. This reflects traditional use, not a proven medical treatment.
Which traditions use Piper wallichii?
Piper wallichii appears in these traditions in our sources: traditional.
What does the scientific evidence say about Piper wallichii?
4 sourced findings are recorded for Piper wallichii; the strongest carries evidence grade D. For example: The ethanol extract of Piper wallichii improved symptoms of DSS-induced ulcerative colitis in mice by affecting inflammatory and immune factors.
How strong is the evidence for Piper wallichii?
The strongest finding for Piper wallichii carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Piper wallichii safe? What are the side effects?
No major safety issues are recorded for Piper wallichii in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Piper wallichii interact with medications?
No drug interactions are recorded for Piper wallichii in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Piper wallichii?
Piper wallichii is also known as: Poivrier de Wallich.
Is Piper wallichii a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T3 Dr. Duke's Ethnobotanical Database public domain (USDA ARS — attribute Dr. Duke's)
- T2 Wallichinine reverses ABCB1-mediated cancer multidrug resistance. literature abstract metadata
- T2 Chemical constituents and antibacterial activity from the stems and leaves of Piper wallichii. literature abstract metadata
- T2 Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis in mice: Involvement of TLR4/NF-κB/COX-2 signaling pathway. literature abstract metadata
- T2 Targeting autophagy to discover the Piper wallichii petroleum ether fraction exhibiting antiaging and anti-Alzheimer's disease effects in Caenorhabditis elegans. literature abstract metadata