Polygonatum kingianum
Polygonatum kingianum
Polygonatum kingianum, a traditional medicine plant, is primarily associated with East Asian herbal practices. While its specific uses are not documented in historical or traditional contexts, studies have shown that its polysaccharides and saponins may improve cognitive functions in zebrafish, indicating potential neuroprotective benefits. Scientific evidence also suggests that the pathogen Aw causes root rot in Polygonatum kingianum, with Penicillium crustosum being another identified causal agent. Research has highlighted multi-target mechanisms involving EGFR, PI3K, HSP90AA1, SRC, and STAT3 pathways for potential treatment of Alzheimer's disease, though these findings are preliminary and need further validation in human studies. Notably, no major safety issues or drug interactions have been recorded for Polygonatum kingianum to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Both PK polysaccharides and saponins improved cognitive functions in zebrafish, with different neuroprotective profiles.
- The study identified potential multi-target mechanisms of selenium-biofortified Polygonatum kingianum involving EGFR, PI3K, HSP90AA1, SRC, and STAT3 in Alzheimer's disease pathways.
- The study identified Penicillium crustosum as the causal agent of root rot in Polygonatum kingianum.
- The main pathogen causing root rot in Polygonatum kingianum is identified as Aspergillus awamori, which upregulates plant defense genes involved in lignin, flavonoids, and plant-pathogen interaction pathways.
- The mitogenomes of putative diploid and tetraploid Polygonatum kingianum show structural differences, including chromosome number and gene copy variations.
Frequently asked questions
What is Polygonatum kingianum?
Polygonatum kingianum (Polygonatum kingianum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Polygonatum kingianum?
5 sourced findings are recorded for Polygonatum kingianum; the strongest carries evidence grade D. For example: Both PK polysaccharides and saponins improved cognitive functions in zebrafish, with different neuroprotective profiles.
How strong is the evidence for Polygonatum kingianum?
The strongest finding for Polygonatum kingianum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Polygonatum kingianum safe? What are the side effects?
No major safety issues are recorded for Polygonatum kingianum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Polygonatum kingianum interact with medications?
No drug interactions are recorded for Polygonatum kingianum in our sources. This does not rule them out — check with a pharmacist.
Is Polygonatum kingianum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Exploring the Mechanism of Selenium-Biofortified Polygonatum Kingianum in Alzheimer's Disease: An Integrated Metabolomics and Network Pharmacology In Silico Study. literature abstract metadata
- T2 Identification of Root Rot Pathogens, Biological Control, and the Mechanism Analysis Underlying Polygonatum kingianum Response to Pathogen Stress. literature abstract metadata
- T2 Comprehensive analyses of different putative ploidy levels in organelle genomes of an important medicinal plant Polygonatum kingianum Collett & Hemsl. literature abstract metadata
- T2 The Effect of Polysaccharides and Saponins from Polygonatum kingianum on Cognitive Dysfunction in an AlCl3-Induced Alzheimer's Disease Zebrafish Model. literature abstract metadata
- T2 First Report and Biological Characterization of Penicillium crustosum Causing Root Rot in Polygonatum kingianum (Yunnan, China). literature abstract metadata