Gambier
Uncaria gambir
Uncaria gambir is a plant traditionally used in Southeast Asian medicine, particularly in Malaysia and Indonesia, though specific traditional uses are not well-documented. Scientific evidence suggests that the ethyl acetate extract of Uncaria gambir (Epi-A) demonstrates potent antimalarial activity both in vitro and in vivo without significant toxicity. The study identified strictosamide and 3α-dihydrocadambine as active compounds, showing notable phosphatase inhibition and vasodilatory effects respectively. Additionally, the extract at doses of 100 mg/L and 200 mg/L enhanced SOD and CAT enzyme activity, with a 200 mg/L dose reducing hepatocellular death by 17.97%. In another study, supplementation with 1% Gambier reduced methane output by 33.43% compared to the control group. To date, no major safety issues or drug interactions have been recorded for Uncaria gambir.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Epi-A showed potent in vitro and good in vivo antimalarial activity without significant toxicity.
- The study identified strictosamide and 3α-dihydrocadambine from Uncaria gambir, showing notable CDC25B phosphatase inhibition and vasodilatory activity, respectively.
- The 100 mg/L and 200 mg/L doses of U. gambir ethyl acetate extract enhanced SOD and CAT enzyme activity, with the 200 mg/L dose reducing hepatocellular death by 17.97%.
- Supplementation with 1% Gambier reduced methane output by 33.43% compared to the control.
Frequently asked questions
What is Gambier?
Gambier (Uncaria gambir) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Gambier?
4 sourced findings are recorded for Gambier; the strongest carries evidence grade D. For example: Epi-A showed potent in vitro and good in vivo antimalarial activity without significant toxicity.
How strong is the evidence for Gambier?
The strongest finding for Gambier carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Gambier safe? What are the side effects?
No major safety issues are recorded for Gambier in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Gambier interact with medications?
No drug interactions are recorded for Gambier in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Gambier?
Gambier is also known as: Гамбир.
Is Gambier a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Comparative effects of Gamal (Gliricidia sepium)-based diets supplemented with Gambier (Uncaria gambir) or direct-fed microbials on rumen fermentation, nutrient digestibility, microbial protein synthesis, and methane mitigation in beef catt literature abstract metadata
- T2 Metabolomic study and valuation of ethyl acetate extract of Uncaria gambir (W. Hunter) Roxb. as a natural antioxidant against lead acetate-induced free radicals. literature abstract metadata
- T2 Chemical components from Uncaria gambir (W.Hunter) Roxb. and their preliminary bioactivities in CDC25B phosphatase inhibition and vasodilatory activity. literature abstract metadata
- T2 Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10. literature abstract metadata