Chinese Chaste Tree
Vitex negundo
Vitex negundo is a plant traditionally used in various folk and alternative medicine practices, particularly in Ayurveda and traditional Chinese medicine. It has been employed for its purported anti-inflammatory and antimicrobial properties, though specific uses vary widely among different cultures. Scientific evidence suggests that Vitex negundo exhibits multiple pharmacological activities, including antioxidant, anti-inflammatory, and hepatoprotective effects; however, the results are not entirely consistent due to variations in research methodologies. A study indicated that a combination of extracts from Allium cepa bulb and Vitex negundo root could mitigate tenofovir-induced renal toxicities in rats, while another found that Vitex negundo leaf extract reduced inflammation associated with acute lung injury by modulating the TLR-4/NF-κB p65/iNOS pathway. Additionally, seventeen bioactive phytoconstituents were identified in Vitex negundo seeds, indicating potential antimicrobial activity. No significant safety concerns or recorded drug interactions have been reported to date.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Vitex negundo showed multiple pharmacological activities including anti-inflammatory, antioxidant, and hepatoprotective effects, but inconsistencies in research design limit definitive conclusions.
- The methanolic extract of Allium cepa bulb and hydroalcoholic extract of Vitex negundo root showed significant antioxidant activity and mitigated tenofovir-induced renal toxicities in a rat model.
- Vitex negundo leaf extract mitigated LPS-induced acute lung injury in mice by reducing inflammation and modulating the TLR-4/NF-κB p65/iNOS pathway.
- The study identified seventeen bioactive phytoconstituents in Vitex negundo seeds, showing potential antimicrobial activity.
Frequently asked questions
What is Chinese Chaste Tree?
Chinese Chaste Tree (Vitex negundo) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese Chaste Tree?
4 sourced findings are recorded for Chinese Chaste Tree; the strongest carries evidence grade A. For example: Vitex negundo showed multiple pharmacological activities including anti-inflammatory, antioxidant, and hepatoprotective effects, but inconsistencies in research design limit definitive conclusions.
How strong is the evidence for Chinese Chaste Tree?
The strongest finding for Chinese Chaste Tree carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese Chaste Tree safe? What are the side effects?
No major safety issues are recorded for Chinese Chaste Tree in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese Chaste Tree interact with medications?
No drug interactions are recorded for Chinese Chaste Tree in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Chinese Chaste Tree?
Chinese Chaste Tree is also known as: Muguet bleu.
Is Chinese Chaste Tree a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Vitex negundo Linn.: A decade of advances in phytochemistry, pharmacological activities, and biotechnological interventions (2015-2025) - A comprehensive review. literature abstract metadata
- T2 Phytochemical profiling of Vitex negundo seeds via UHPLC-QTOF-MS/MS analyses with antimicrobial evaluation and in silico targeting of DNA Gyrase B and Secreted Aspartic Proteinase 2 (SAP2). literature abstract metadata
- T2 Unravelling the potential of Vitex negundo leaf extract in LPS-induced acute lung injury in mice through modulation of the TLR-4/NF-κB p65/iNOS pathway: Insights from integrated phytochemical characterization, in silico, and in vivo analysi literature abstract metadata
- T2 Xanthine oxidase inhibition by medicinal plants mitigates tenofovir-induced nephrotoxicity: a comprehensive computational and experimental study. literature abstract metadata