Chinese Chaste Tree
Vitex negundo
Vitex negundo, a plant traditionally used in various folk medicine practices but with no specific documented traditional uses, has shown promise across multiple pharmacological activities. Research indicates potential anti-inflammatory and antioxidant effects, as well as hepatoprotective properties; however, the evidence is not yet conclusive due to variability in study designs. A study found that both Vitex negundo root extract and Allium cepa bulb methanolic extract provided significant antioxidant activity and mitigated renal toxicities caused by tenofovir in rats. Additionally, seventeen bioactive phytoconstituents were identified in the seeds of Vitex negundo, which demonstrated potential antimicrobial activity. The leaf extract also showed protection against LPS-induced acute lung injury through modulation of the TLR-4/NF-κB p65/iNOS pathway. No major safety concerns or reported drug interactions have been recorded for this plant, but further research is needed to fully understand its therapeutic potential and safety profile.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Vitex negundo showed multiple pharmacological activities including anti-inflammatory, antioxidant, and hepatoprotective effects, but inconsistencies in research design limit definitive conclusions.
- The methanolic extract of Allium cepa bulb and hydroalcoholic extract of Vitex negundo root showed significant antioxidant activity and mitigated tenofovir-induced renal toxicities in a rat model.
- Vitex negundo leaf extract mitigated LPS-induced acute lung injury in mice by reducing inflammation and modulating the TLR-4/NF-κB p65/iNOS pathway.
- The study identified seventeen bioactive phytoconstituents in Vitex negundo seeds, showing potential antimicrobial activity.
Frequently asked questions
What is Chinese Chaste Tree?
Chinese Chaste Tree (Vitex negundo) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese Chaste Tree?
4 sourced findings are recorded for Chinese Chaste Tree; the strongest carries evidence grade A. For example: Vitex negundo showed multiple pharmacological activities including anti-inflammatory, antioxidant, and hepatoprotective effects, but inconsistencies in research design limit definitive conclusions.
How strong is the evidence for Chinese Chaste Tree?
The strongest finding for Chinese Chaste Tree carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese Chaste Tree safe? What are the side effects?
No major safety issues are recorded for Chinese Chaste Tree in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese Chaste Tree interact with medications?
No drug interactions are recorded for Chinese Chaste Tree in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Chinese Chaste Tree?
Chinese Chaste Tree is also known as: Muguet bleu.
Is Chinese Chaste Tree a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Vitex negundo Linn.: A decade of advances in phytochemistry, pharmacological activities, and biotechnological interventions (2015-2025) - A comprehensive review. literature abstract metadata
- T2 Phytochemical profiling of Vitex negundo seeds via UHPLC-QTOF-MS/MS analyses with antimicrobial evaluation and in silico targeting of DNA Gyrase B and Secreted Aspartic Proteinase 2 (SAP2). literature abstract metadata
- T2 Unravelling the potential of Vitex negundo leaf extract in LPS-induced acute lung injury in mice through modulation of the TLR-4/NF-κB p65/iNOS pathway: Insights from integrated phytochemical characterization, in silico, and in vivo analysi literature abstract metadata
- T2 Xanthine oxidase inhibition by medicinal plants mitigates tenofovir-induced nephrotoxicity: a comprehensive computational and experimental study. literature abstract metadata