Stephania
Stephania
Stephania 是一种传统植物，在各种草药医学实践中广泛使用，特别是在亚洲。尽管其具体的传统用途没有很好地记录下来，但它因其在不同条件下的潜在药理作用而被研究。科学证据表明，从 Stephania venosa 中提取的化合物如 crebanine 可能通过调节信号通路抑制肝细胞癌细胞的增殖和侵袭从而具有抗肿瘤效果。此外，Stephania 种类中发现的 cepharanthine 也显示出抑制 NLRP3 炎症小体诱导的焦亡并表现出显著的抗锥虫活性且安全性高。体外和体内研究表明它可能用于治疗乳腺癌。基于当前数据的安全性问题很小，并且没有报告有关重要药物相互作用的证据。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 来自 Stephania venosa 的克雷班宁通过调节 EZH2/DUSP1/Akt 信号通路抑制肝细胞癌的增殖和侵袭。
- cepharanthine通过ARIH2介导的NLRP3降解抑制由NLRP3炎糜子引起的细胞焦亡。
- cepharanthine 抑制了克隆形成，诱导凋亡，并损害三阴性乳腺癌细胞的溶酶体功能。
- cepharanthine在体外和体内均显示出显著的抗锥虫活性，且安全性高。
- 研究在Stephania japonica var. discolor中鉴定了十二个新的哈斯巴南生物碱，其中一些显示出比米诺环素更好的体外一氧化氮抑制效果。
Frequently asked questions
What is Stephania?
Stephania (Stephania) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Stephania?
5 sourced findings are recorded for Stephania; the strongest carries evidence grade D. For example: 来自 Stephania venosa 的克雷班宁通过调节 EZH2/DUSP1/Akt 信号通路抑制肝细胞癌的增殖和侵袭。
How strong is the evidence for Stephania?
The strongest finding for Stephania carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Stephania safe? What are the side effects?
No major safety issues are recorded for Stephania in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Stephania interact with medications?
No drug interactions are recorded for Stephania in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Stephania?
Stephania is also known as: Стефания (растение).
Is Stephania a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells. literature abstract metadata
- T2 Dual assessment of cepharanthine: In vitro and in vivo inhibitory effects on multi-host haemoprotozoa, Trypanosoma evansi. literature abstract metadata
- T2 Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis through ARIH2-mediated degradation of NLRP3. literature abstract metadata
- T2 EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression. literature abstract metadata
- T2 Novel hasubanan alkaloids and dimers from Stephania japonica var. discolor: phytochemical profile and anti-neuroinflammatory activity. literature abstract metadata