Stephania
Stephania
Stephania 是一种传统上在亚洲和南美多种民间医学体系中使用的植物属。尽管对 Stephania 种类的具体用途尚未广泛记录，但研究主要集中在从这些植物中提取的某些化合物上。例如，来自 Stephania venosa 的 crebanine 展现出潜在的抗癌特性，通过调节 EZH2/DUSP1/Akt 信号通路抑制肝细胞癌细胞的增殖和侵袭。此外，存在于 Stephania 种类中的 cepharanthine 表现出抗炎作用，通过抑制 NLRP3 炎症小体诱导的焦亡，并显示出具有高安全性的显著抗锥虫活性。体外和体内研究表明，它可能作为三阴性乳腺癌细胞的抗癌剂发挥作用，机制包括抑制克隆形成、诱导凋亡和损害溶酶体功能。迄今为止尚未发现主要的安全问题或药物相互作用，但进一步的研究对于完全了解 Stephania 种类的治疗应用及其潜在风险至关重要。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 来自 Stephania venosa 的克雷班宁通过调节 EZH2/DUSP1/Akt 信号通路抑制肝细胞癌的增殖和侵袭。
- cepharanthine通过ARIH2介导的NLRP3降解抑制由NLRP3炎糜子引起的细胞焦亡。
- cepharanthine 抑制了克隆形成，诱导凋亡，并损害三阴性乳腺癌细胞的溶酶体功能。
- cepharanthine在体外和体内均显示出显著的抗锥虫活性，且安全性高。
- 研究在Stephania japonica var. discolor中鉴定了十二个新的哈斯巴南生物碱，其中一些显示出比米诺环素更好的体外一氧化氮抑制效果。
Frequently asked questions
What is Stephania?
Stephania (Stephania) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Stephania?
5 sourced findings are recorded for Stephania; the strongest carries evidence grade D. For example: 来自 Stephania venosa 的克雷班宁通过调节 EZH2/DUSP1/Akt 信号通路抑制肝细胞癌的增殖和侵袭。
How strong is the evidence for Stephania?
The strongest finding for Stephania carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Stephania safe? What are the side effects?
No major safety issues are recorded for Stephania in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Stephania interact with medications?
No drug interactions are recorded for Stephania in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Stephania?
Stephania is also known as: Стефания (растение).
Is Stephania a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells. literature abstract metadata
- T2 Dual assessment of cepharanthine: In vitro and in vivo inhibitory effects on multi-host haemoprotozoa, Trypanosoma evansi. literature abstract metadata
- T2 Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis through ARIH2-mediated degradation of NLRP3. literature abstract metadata
- T2 EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression. literature abstract metadata
- T2 Novel hasubanan alkaloids and dimers from Stephania japonica var. discolor: phytochemical profile and anti-neuroinflammatory activity. literature abstract metadata