Stephania
Stephania
Stephania is a traditional plant used in various herbal medicine practices, particularly in Asia. While its specific traditional uses are not well-documented, it has been studied for its potential medicinal properties across different conditions. Scientific evidence suggests that compounds like crebanine from Stephania venosa may have anti-cancer effects by suppressing the proliferation and invasion of hepatocellular carcinoma cells through modulation of signaling pathways. Additionally, cepharanthine, another compound found in Stephania species, has shown promise in inhibiting the NLRP3 inflammasome-induced pyroptosis and exhibiting significant anti-trypanosomal activity with a high safety profile. In vitro and in vivo studies indicate its potential for treating breast cancer as well. Safety concerns are minimal based on current data, and there is no reported evidence of significant drug interactions.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Crebanine from Stephania venosa suppresses hepatocellular carcinoma proliferation and invasion by modulating the EZH2/DUSP1/Akt signaling pathway.
- Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis by promoting NLRP3 degradation via ARIH2.
- Cepharanthine inhibited colony formation, induced apoptosis, and impaired lysosomal function in triple-negative breast cancer cells.
- Cepharanthine showed significant in vitro and in vivo anti-trypanosomal activity with high safety profile.
- The study identified twelve novel hasubanan alkaloids from Stephania japonica var. discolor, with some showing better inhibitory effects on nitric oxide production than minocycline in vitro.
Frequently asked questions
What is Stephania?
Stephania (Stephania) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Stephania?
5 sourced findings are recorded for Stephania; the strongest carries evidence grade D. For example: Crebanine from Stephania venosa suppresses hepatocellular carcinoma proliferation and invasion by modulating the EZH2/DUSP1/Akt signaling pathway.
How strong is the evidence for Stephania?
The strongest finding for Stephania carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Stephania safe? What are the side effects?
No major safety issues are recorded for Stephania in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Stephania interact with medications?
No drug interactions are recorded for Stephania in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Stephania?
Stephania is also known as: Стефания (растение).
Is Stephania a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells. literature abstract metadata
- T2 Dual assessment of cepharanthine: In vitro and in vivo inhibitory effects on multi-host haemoprotozoa, Trypanosoma evansi. literature abstract metadata
- T2 Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis through ARIH2-mediated degradation of NLRP3. literature abstract metadata
- T2 EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression. literature abstract metadata
- T2 Novel hasubanan alkaloids and dimers from Stephania japonica var. discolor: phytochemical profile and anti-neuroinflammatory activity. literature abstract metadata