Stephania

Stephania is a genus of plants traditionally used in various Asian and South American traditional medicine systems. While specific uses for Stephania species have not been extensively documented, research has focused on certain compounds derived from these plants. For instance, crebanine from Stephania venosa has shown potential anti-cancer properties by suppressing the proliferation and invasion of hepatocellular carcinoma cells through modulation of the EZH2/DUSP1/Akt signaling pathway. Additionally, cepharanthine, another compound found in Stephania species, exhibits anti-inflammatory effects by inhibiting NLRP3 inflammasome-induced pyroptosis and shows significant anti-trypanosomal activity with a high safety profile. In vitro and in vivo studies indicate its potential as an anticancer agent against triple-negative breast cancer cells through mechanisms that include colony formation inhibition, apoptosis induction, and impairment of lysosomal function. No major safety concerns or recorded drug interactions have been noted thus far, but further research is needed to fully understand the therapeutic applications and potential risks associated with Stephania species.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.