Citrus suavissima

Citrus suavissima, also known as sweet orange, is a traditional plant with origins in Southeast Asia. While its use has been documented historically for various purposes such as culinary and aromatic applications, no specific traditional medicinal uses have been recorded. Scientific evidence from studies indicates that enzymatically modified pectins derived from the peel of Ougan (a variety of Citrus suavissima) may possess anti-proliferative properties against HeLa cells, with EMP2 showing slightly better efficiency due to its lower molecular weight and higher HG content. Additionally, a study identified 487 differentially expressed proteins associated with sporopollenin biosynthesis and pollen exine formation in a male sterile mutant of Citrus suavissima compared to the wild type, though this finding does not directly relate to human health applications. The juice of Ougan showed tendencies to inhibit CYP1A2 and CYP2C19 while inducing CYP2C9, but did not influence CYP2D6 activity; naringin, a flavonoid found in citrus fruits, was observed to potentially bind to ACE2 and inhibit proinflammatory cytokines expression. No major safety issues or drug interactions have been recorded for Citrus suavissima based on the available data.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.