Clerodendrum petasites
Clerodendrum petasites
Clerodendrum petasites is a plant traditionally used in various herbal practices but lacks specific documented uses. Scientific studies have shown that topical formulations of its extracts can deliver phenolic compounds such as vanillic acid, nepetin, and hispidulin to the skin, indicating potential dermal benefits. Clerodendrum petasites has demonstrated significant antinociceptive and anti-inflammatory effects without causing adverse central nervous system impacts at tested doses. Laboratory studies also suggest that compounds from this plant, such as CpEA and hesperetin, exhibit strong anti-inflammatory properties by reducing cytokine release and inhibiting inflammatory gene expressions in cell cultures. The combination of Clerodendrum petasites with other plants has shown potential for anti-allergic, anti-inflammatory, and antimicrobial activities. To date, no major safety concerns or drug interactions have been recorded, though further research is needed to fully understand its effects and applications.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Topical formulations of Clerodendrum petasites extracts showed variable dermal delivery of phenolic compounds, with vanillic acid, nepetin, and hispidulin detected in the stratum corneum.
- Clerodendrum petasites extract showed significant antinociceptive and anti-inflammatory effects without adverse CNS impacts at tested doses.
- CpEA and hesperetin from Clerodendrum petasites showed greater anti-inflammatory properties by reducing cytokine releases and inhibiting inflammatory gene expressions in A549 cells.
- The combination of Clerodendrum petasites and other plants showed potential anti-allergic, anti-inflammatory, and antimicrobial activities in vitro.
Frequently asked questions
What is Clerodendrum petasites?
Clerodendrum petasites (Clerodendrum petasites) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Clerodendrum petasites?
4 sourced findings are recorded for Clerodendrum petasites; the strongest carries evidence grade B. For example: Topical formulations of Clerodendrum petasites extracts showed variable dermal delivery of phenolic compounds, with vanillic acid, nepetin, and hispidulin detected in the stratum corneum.
How strong is the evidence for Clerodendrum petasites?
The strongest finding for Clerodendrum petasites carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Clerodendrum petasites safe? What are the side effects?
No major safety issues are recorded for Clerodendrum petasites in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Clerodendrum petasites interact with medications?
No drug interactions are recorded for Clerodendrum petasites in our sources. This does not rule them out — check with a pharmacist.
Is Clerodendrum petasites a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Topical formulation and dermal delivery of active phenolic compounds in the Thai medicinal plant--Clerodendrum petasites S. Moore. literature abstract metadata
- T2 Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway. literature abstract metadata
- T2 Antinociceptive efficacy of Clerodendrum petasites S. Moore, a Thai medicinal plant, and its CNS safety profiles. literature abstract metadata
- T2 In vitro biological activities of a combination of Ha-rak remedy, Piper betle, and Garcinia mangostana for the treatment of atopic dermatitis. literature abstract metadata