Fan-leaf mountain yam
Dioscorea nipponica
Dioscorea nipponica is a plant traditionally not associated with any specific medicinal uses. Scientific evidence suggests that mild drought conditions can significantly enhance diosgenin content in its rhizomes, increasing it by 103.19 ± 2.63% compared to control conditions. The plant has shown potential anti-proliferative effects both in vitro and in vivo, with studies indicating a reduction in tumor volume ranging from 26-50%. Additionally, Dioscorea nipponica has been found to reduce pro-inflammatory cytokines and inhibit enzymes involved in neuroinflammation. A haplotype-resolved genome of the plant has also been sequenced, providing insights into dioscin biosynthesis and revealing four principal clades with varying ploidy levels. No major safety issues or drug interactions have been recorded for this plant.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Mild drought significantly increased diosgenin content in rhizomes of Dioscorea nipponica by 103.19 ± 2.63% compared to control conditions.
- Both PGP and DN significantly inhibited DNA synthesis and cell cycle re-entry (G0-to-G1 transition) in vitro, and reduced tumor volume by 26-50% in vivo.
- The study presents a haplotype-resolved genome of Dioscorea nipponica, identifying key genes in dioscin biosynthesis and revealing four principal clades with varying ploidy levels.
- The study found that Dioscorea nipponica reduces pro-inflammatory cytokines and inhibits enzymes involved in neuroinflammation.
- Dioscorea nipponica shows multi-target effects by modulating inflammatory and apoptotic pathways in autoimmune diseases, but large-scale trials are needed to confirm its therapeutic potential.
- Significant differences were observed in the secondary metabolites between cultivated and wild populations of Dioscorea nipponica, despite genetic stability and higher diversity.
- The UGT73 subfamily in D. nipponica shows diverse catalytic functions in steroidal saponin glycosylation, with some functions independently evolved by different families.
Frequently asked questions
What is Fan-leaf mountain yam?
Fan-leaf mountain yam (Dioscorea nipponica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Fan-leaf mountain yam?
7 sourced findings are recorded for Fan-leaf mountain yam; the strongest carries evidence grade A. For example: Mild drought significantly increased diosgenin content in rhizomes of Dioscorea nipponica by 103.19 ± 2.63% compared to control conditions.
How strong is the evidence for Fan-leaf mountain yam?
The strongest finding for Fan-leaf mountain yam carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Fan-leaf mountain yam safe? What are the side effects?
No major safety issues are recorded for Fan-leaf mountain yam in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Fan-leaf mountain yam interact with medications?
No drug interactions are recorded for Fan-leaf mountain yam in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Fan-leaf mountain yam?
Fan-leaf mountain yam is also known as: Диоскорея ниппонская.
Is Fan-leaf mountain yam a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature. literature abstract metadata
- T2 Haplotype-resolved genome and population genomics provide insights into dioscin biosynthesis and evolutionary history of the medicinal species Dioscorea nipponica. literature abstract metadata
- T2 Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27. literature abstract metadata
- T2 Dioscorea nipponica Makino: Unraveling multi-target mechanisms and clinical potential in autoimmune disease therapy. literature abstract metadata
- T2 Mild Drought Promotes Biomass Accumulation and Increases Diosgenin Content in Rhizomes of Dioscorea nipponica. literature abstract metadata
- T2 Habitat changes due to cultivation alter the genetic diversity and secondary metabolic changes of medicinal plants. literature abstract metadata
- T2 Chromosome-scale genome of Dioscorea nipponica and functional diversification of the DnUGT73 subfamily in steroidal saponin glycosylation. literature abstract metadata