African milkbush

Euphorbia tirucalli

Euphorbia tirucalli, commonly known as the pencil cactus or milk bush, is a plant native to tropical and subtropical regions of Africa, Asia, Australia, and South America. Traditionally, its use has not been extensively recorded in any specific medical practices. Scientific studies have shown that stem extracts from Euphorbia tirucalli exhibit cytotoxic activity against breast cancer cells, with lupeol and β-amyrin demonstrating strong binding affinities to relevant targets. However, the evidence is preliminary and more research is needed to confirm these findings. In a study involving rats, latex ingestion was observed to alter cardiac hemodynamics and increase oxidative stress without affecting blood pressure. The plant has also been found to contain compounds with varying antimicrobial activities against different strains of Klebsiella pneumoniae. No major safety issues or drug interactions have been recorded for Euphorbia tirucalli; however, further research is necessary to fully understand its potential effects and applications.

At a glance
Best evidence
D
Cautions

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Euphorbia tirucalli stem extracts showed cytotoxic and antioxidant activity against breast cancer cells, with lupeol and β-amyrin exhibiting strong binding affinities to relevant targets. D PMID
  • Euphorbia tirucalli latex ingestion in rats altered cardiac hemodynamics and increased oxidative stress without changing blood pressure. D PMID
  • The study identified 25 compounds from Vietnamese Euphorbia tirucalli and found its PE extract to be most effective against Jurkat cells with an IC50 of 22.38 μg.mL-1. D PMID
  • Euphorbia tirucalli latex contains compounds with varying antimicrobial activities against different strains of Klebsiella pneumoniae. D PMID

Frequently asked questions

What is African milkbush?

African milkbush (Euphorbia tirucalli) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about African milkbush?

4 sourced findings are recorded for African milkbush; the strongest carries evidence grade D. For example: Euphorbia tirucalli stem extracts showed cytotoxic and antioxidant activity against breast cancer cells, with lupeol and β-amyrin exhibiting strong binding affinities to relevant targets.

How strong is the evidence for African milkbush?

The strongest finding for African milkbush carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is African milkbush safe? What are the side effects?

No major safety issues are recorded for African milkbush in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does African milkbush interact with medications?

No drug interactions are recorded for African milkbush in our sources. This does not rule them out — check with a pharmacist.

What are the common names of African milkbush?

African milkbush is also known as: Молочай тирукалли, Bois de lait.

Is African milkbush a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 GC-MS metabolite profiling and multi-target Docking analysis of Calotropis procera and Euphorbia tirucalli stem extracts for cytotoxicity and antioxidant activity. literature abstract metadata
  2. T2 Further constituents and bioactivities of Vietnamese Euphorbia tirucalli L. literature abstract metadata
  3. T2 Phytochemical profiling of Euphorbia tirucalli Linn. latex and evaluation of its in vitro antibacterial activity against resistant Klebsiella pneumoniae: an integrative network pharmacology and molecular dynamics simulation study. literature abstract metadata
  4. T2 Euphorbia tirucalli Latex Ingestion Modifies Heart Function and Increases Myocyte Levels of Oxidative Stress in Normotensive Rats. literature abstract metadata