Korean pasque-flower
Pulsatilla koreana
Pulsatilla koreana is a traditional medicine plant native to East Asia. While its use in specific traditional practices has not been extensively documented, studies have shown promising results for various applications. Scientific evidence indicates that compounds from Pulsatilla koreana, particularly Pk-AuNps, exhibit potent anti-inflammatory effects by inhibiting the production of nitric oxide (NO) and prostaglandin E2 (PGE2), as well as downregulating iNOS and COX-2 gene expression in LPS-stimulated macrophages. Additionally, water extracts from Pulsatilla koreana have been found to suppress osteoclast differentiation and alleviate bone loss in ovariectomized mice, suggesting potential benefits for bone health. The plant also demonstrated significant cytotoxicity against A549 lung cancer cells when silver nanoparticles were synthesized using its root extract. Moreover, Pulsatilla koreana Nakai extract alleviated atopy symptoms in mice by restoring skin barrier-related factor levels, indicating possible applications in treating atopic dermatitis. To date, no major safety concerns or recorded drug interactions have been identified for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Pk-AuNps from Pulsatilla koreana showed potent anti-inflammatory effects by inhibiting NO and PGE2 production and downregulating iNOS and COX-2 gene expression in LPS-stimulated macrophages.
- Water extracts of Pulsatilla koreana suppressed osteoclast differentiation and alleviated bone loss in ovariectomized mice.
- The study found that silver nanoparticles synthesized using Pulsatilla koreana root extract showed significant cytotoxicity against A549 lung cancer cells.
- Pulsatilla koreana Nakai extract alleviated atopy symptoms in mice and restored skin barrier-related factor levels, suggesting potential for treating atopic dermatitis.
Frequently asked questions
What is Korean pasque-flower?
Korean pasque-flower (Pulsatilla koreana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Korean pasque-flower?
4 sourced findings are recorded for Korean pasque-flower; the strongest carries evidence grade D. For example: Pk-AuNps from Pulsatilla koreana showed potent anti-inflammatory effects by inhibiting NO and PGE2 production and downregulating iNOS and COX-2 gene expression in LPS-stimulated macrophages.
How strong is the evidence for Korean pasque-flower?
The strongest finding for Korean pasque-flower carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Korean pasque-flower safe? What are the side effects?
No major safety issues are recorded for Korean pasque-flower in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Korean pasque-flower interact with medications?
No drug interactions are recorded for Korean pasque-flower in our sources. This does not rule them out — check with a pharmacist.
Is Korean pasque-flower a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Water Extract of Pulsatilla koreana Nakai Inhibits Osteoclast Differentiation and Alleviates Ovariectomy-Induced Bone Loss. literature abstract metadata
- T2 Pulsatilla koreana Nakai Extract Attenuates Atopic Dermatitis-like Symptoms by Regulating Skin Barrier Factors and Inhibiting the JAK/STAT Pathway. literature abstract metadata
- T2 Modulation of LPS-induced RAW 264.7 macrophages by Pulsatilla koreana-synthesized gold nanoparticles. literature abstract metadata
- T2 Green synthesis, characterization, and anticancer activity of silver nanoparticles via Pulsatilla koreana root extract. literature abstract metadata