FolkKB

Astral Sage

Salvia miltiorrhiza

Salvia miltiorrhiza, commonly known as Danshen, is a traditional Chinese herb. Traditionally, it has been used in Chinese medicine for various conditions such as cardiovascular disorders and menstrual issues, though specific uses are not extensively recorded. Scientific evidence suggests that overexpression of SmGA2ox4 enhances the salt tolerance and tanshinone accumulation in S. miltiorrhiza, indicating potential benefits related to environmental stress resistance. Tanshinones from this plant have shown multi-target neuroprotective effects in cerebral ischemia/reperfusion injury through various mechanisms, though evidence is still being explored. Additionally, studies indicate that SAB can synergistically enhance the activity of azoles against drug-resistant C. glabrata both in vitro and in vivo, while PB-SM administration improved immune function in cyclophosphamide-induced immunosuppressed mice, with individual and enhanced effects from PCA and TanIIA. Notably, no major safety issues or significant drug interactions have been recorded for S. miltiorrhiza to date.

At a glance
Best evidence
A
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • SmGA2ox4 overexpression enhances salt tolerance and tanshinone accumulation in Salvia miltiorrhiza. D PMID
  • Tanshinones from Salvia miltiorrhiza show multi-target neuroprotective effects in cerebral ischemia/reperfusion injury through various mechanisms. D PMID
  • SAB synergistically enhances azoles activity against drug-resistant C. glabrata both in vitro and in vivo. D PMID
  • PB-SM administration improved immune function in cyclophosphamide-induced immunosuppressed mice, with individual and enhanced effects from PCA and TanIIA. D PMID
  • Salvia miltiorrhiza-derived interventions significantly improved bone density, structure, and metabolism markers in animal models of osteoporosis. A PMID
  • The study found that formononetin and salvianolic acid B suppress pancreatic cancer progression by downregulating MBOAT2 and inhibiting the JAK/STAT signaling pathway. D PMID
  • The study found that Qishen Yiqi Dripping Pills alleviate myocardial ischemia-reperfusion-induced fibrotic injury by targeting the TGF-β/Periostin pathway. D PMID
  • Qishen paste improved cardiac conduction and function in heart failure mice by upregulating Cx43 in cardiac resident macrophages. D PMID
  • The study finds that Atf3 deficiency significantly impacts perivascular adipose tissue structure and function, suggesting Atf3's importance in adipose-vascular crosstalk. D PMID
  • Salvia miltiorrhiza extract showed high efficacy in enhancing left ventricular ejection fraction in heart failure patients. A PMID
  • Salvia miltiorrhiza extract (SAGX) showed a significantly greater reduction in total IPSS compared to saw palmetto, with improvements in storage symptoms and QoL. D PMID

Frequently asked questions

What is Astral Sage?

Astral Sage (Salvia miltiorrhiza) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Astral Sage?

11 sourced findings are recorded for Astral Sage; the strongest carries evidence grade A. For example: SmGA2ox4 overexpression enhances salt tolerance and tanshinone accumulation in Salvia miltiorrhiza.

How strong is the evidence for Astral Sage?

The strongest finding for Astral Sage carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Astral Sage safe? What are the side effects?

No major safety issues are recorded for Astral Sage in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Astral Sage interact with medications?

No drug interactions are recorded for Astral Sage in our sources. This does not rule them out — check with a pharmacist.

Is Astral Sage a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Protocatechuic acid and tanshinone IIA improve cyclophosphamide-induced immunosuppression. literature abstract metadata
  2. T2 Salvianolic acid B synergizes with azoles against Candida glabrata cells in vulvovaginal candidiasis. literature abstract metadata
  3. T2 Neurochemical Mechanisms Underlying Tanshinone-Mediated Neuroprotection and Formulation Strategies in Cerebral Ischemia/Reperfusion Injury. literature abstract metadata
  4. T2 SmGA2ox4 plays a positive role in improving the salt tolerance and tanshinone accumulation of Salvia miltiorrhiza. literature abstract metadata
  5. T2 Qishen Paste Improves Cardiac Conduction in Heart Failure by Regulating Cardiac Resident Macrophage Connexin43. literature abstract metadata
  6. T2 Qishen Yiqi Dripping Pills Alleviate Myocardial Ischemia-Reperfusion-Induced Fibrotic Injury by Inhibiting Fibroblast Activation via the Transforming Growth Factor-Beta/Periostin Pathway. literature abstract metadata
  7. T2 Targeting pancreatic cancer progression: The formononetin and salvianolic acid B combination suppresses JAK/STAT signaling via MBOAT2 downregulation. literature abstract metadata
  8. T2 Pharmacological effects of Salvia miltiorrhiza-derived interventions on osteoporosis in animal models: a systematic review and meta-analysis. literature abstract metadata
  9. T2 Efficacy of plant extracts in heart failure patients: a systematic review and network meta-analysis. literature abstract metadata
  10. T2 Efficacy and Safety of Salvia miltiorrhiza Extract (SAGX) Compared with Saw Palmetto in Men with Lower Urinary Tract Symptoms: A 12-Week, Randomized, Double-Blind, Parallel-Group Pilot Study. literature abstract metadata
  11. T2 ATF3 in Metabolic Homeostasis and Vascular Disease: Integrating Bibliometric Evidence with Therapeutic Potential. literature abstract metadata

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