Sophora exigua
Sophora exigua
Sophora exigua, a traditional Chinese medicinal plant, has not been extensively documented for specific uses within its tradition. Scientific studies have shown that extracts from Sophora exigua exhibit anti-inflammatory, anti-proliferative, and anti-metastatic effects on lung cancer cells through NLRP3 inflammasome inhibition. The ethanolic extract of the root also demonstrated antioxidant properties, while the aqueous extract showed antimalarial activity in mice. This suggests potential bioactive compounds for biopesticide development from agri-food by-products. Sophoraflavanone G has been found to inhibit WT1 protein expression and induce cell cycle arrest and apoptosis in acute myeloid leukemia cells. No major safety issues or drug interactions have been recorded, but further research is needed to fully understand its potential benefits and applications.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Sophora exigua extract and its active compounds, exiguaflavanone A and exiguaflavanone B, showed anti-inflammatory, anti-proliferative, and anti-metastatic effects on lung cancer cells through NLRP3 inflammasome inhibition.
- The ethanolic extract of Sophora exigua root showed antioxidant properties, while the aqueous extract exhibited antimalarial activity in mice.
- This systematic review suggests that agri-food by-products, such as those from olive, potato, banana, citrus, and winery industries, may serve as potential sources of bioactive compounds for biopesticide development.
- Sophoraflavanone G from Sophora exigua inhibits WT1 protein expression and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.
- The ethyl acetate fraction of Sophora exigua showed high antioxidant activity, and its liposomal formulation maintained this property.
Frequently asked questions
What is Sophora exigua?
Sophora exigua (Sophora exigua) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Sophora exigua?
5 sourced findings are recorded for Sophora exigua; the strongest carries evidence grade A. For example: Sophora exigua extract and its active compounds, exiguaflavanone A and exiguaflavanone B, showed anti-inflammatory, anti-proliferative, and anti-metastatic effects on lung cancer cells through NLRP3 inflammasome inhibition.
How strong is the evidence for Sophora exigua?
The strongest finding for Sophora exigua carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Sophora exigua safe? What are the side effects?
No major safety issues are recorded for Sophora exigua in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Sophora exigua interact with medications?
No drug interactions are recorded for Sophora exigua in our sources. This does not rule them out — check with a pharmacist.
Is Sophora exigua a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Antioxidant and antimalarial properties of Sophora exigua Craib. root extract in Plasmodium berghei-infected mice. literature abstract metadata
- T2 Suppression of inflammation-induced lung cancer cells proliferation and metastasis by exiguaflavanone A and exiguaflavanone B from Sophora exigua root extract through NLRP3 inflammasome pathway inhibition. literature abstract metadata
- T2 Antioxidant activity of Sophora exigua and liposome development of its powerful extract. literature abstract metadata
- T2 Sophoraflavanone G from Phit-Sanat (Sophora Exigua Craib) inhibits WT1 protein expression and induces cell cycle arrest and apoptosis in acute myeloid leukemia. literature abstract metadata
- T2 Agri-Food Biowaste Bioactives for Biopesticides: A Circular Economy Solution with Industry 4.0? literature abstract metadata