stephania-root
Stephania tetrandra
Stephania tetrandra is a traditional Chinese medicinal plant used in various herbal remedies. Its use spans several centuries, though specific traditional applications are not well-documented. Scientific research suggests potential benefits for treating cisplatin-resistant ovarian cancer through the induction of senescence in circulating tumor cells and identifying key targets and mechanisms. Additionally, tetrandrine from Stephania tetrandra has shown promise in protecting cardiomyocytes under hypoxic conditions and modulating autophagy to reduce SARS-CoV-2 replication in lung epithelial cells. However, these findings are preliminary and require further validation. No significant safety concerns or drug interactions have been reported, though comprehensive clinical trials are still needed to fully understand its efficacy and safety profile.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Fangchinoline from Stephania tetrandra induces senescence in circulating tumor cells, reducing metastasis in mouse models without notable toxicity.
- This study identified potential targets and mechanisms for Stephania tetrandra in treating cisplatin-resistant ovarian cancer through network pharmacology and molecular docking.
- Tetrandrine from Stephania tetrandra showed improved cardiomyocyte viability and reduced LDH release under hypoxia/reoxygenation conditions, suggesting potential for protecting against myocardial injury.
- Tetrandrine modulates autophagy and reduces SARS-CoV-2 replication in lung epithelial cells, involving both autophagy-dependent and -independent mechanisms.
Frequently asked questions
What is stephania-root?
stephania-root (Stephania tetrandra) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about stephania-root?
4 sourced findings are recorded for stephania-root; the strongest carries evidence grade D. For example: Fangchinoline from Stephania tetrandra induces senescence in circulating tumor cells, reducing metastasis in mouse models without notable toxicity.
How strong is the evidence for stephania-root?
The strongest finding for stephania-root carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is stephania-root safe? What are the side effects?
No major safety issues are recorded for stephania-root in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does stephania-root interact with medications?
No drug interactions are recorded for stephania-root in our sources. This does not rule them out — check with a pharmacist.
What are the common names of stephania-root?
stephania-root is also known as: Стефания четырёхтычинковая.
Is stephania-root a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Exploring the mechanism of Stephania tetrandra S. Moore in the treatment of cisplatin resistance against ovarian cancer through integration of network pharmacology and molecular docking. literature abstract metadata
- T2 Fangchinoline suppresses melanoma metastasis by inducing senescence of circulating tumor cells. literature abstract metadata
- T2 The protective effects of alkaloids from Stephania tetrandra S. Moore on H9C2 cardiomyocytes. literature abstract metadata
- T2 Tetrandrine-driven autophagy suppresses SARS-CoV-2 replication by modulating cholesterol and IGF signaling pathways. literature abstract metadata