candyleaf
Stevia rebaudiana
Stevia rebaudiana is a plant native to South America and widely used as a natural sweetener. Traditionally, its use has not been documented in any specific medical practices or cultures. Scientific evidence suggests that stevioside may extend lifespan and improve healthspan in nematodes through the activation of the ATFS-1-mediated UPRmt pathway. Additionally, studies indicate that stevia extract can partially alleviate inflammatory injury in mice by inhibiting the TLR4/MYD88/NF-κB signaling pathway. Research has also identified a cluster of UGT76G genes associated with variations in steviol glycoside composition, which may influence taste quality. To date, no significant safety concerns or drug interactions have been reported for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Stevioside extended lifespan and healthspan in C. elegans by activating the ATFS-1-mediated UPRmt pathway.
- Raman spectroscopy can distinguish between naturally occurring, fermentation-derived, and enzyme-assisted bioconverted Rebaudioside M sources.
- The study identified a cluster of UGT76G genes linked to variations in steviol glycoside composition, contributing to differences in taste quality.
- Stevia rebaudiana extract partially alleviated LPS-induced spleen inflammatory injury in mice by inhibiting the TLR4/MYD88/NF-κB signaling pathway.
- The study generated a detailed phytochemical profile of Stevia rebaudiana, identifying 14 compounds and quantifying eight major metabolites.
Frequently asked questions
What is candyleaf?
candyleaf (Stevia rebaudiana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about candyleaf?
5 sourced findings are recorded for candyleaf; the strongest carries evidence grade D. For example: Stevioside extended lifespan and healthspan in C. elegans by activating the ATFS-1-mediated UPRmt pathway.
How strong is the evidence for candyleaf?
The strongest finding for candyleaf carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is candyleaf safe? What are the side effects?
No major safety issues are recorded for candyleaf in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does candyleaf interact with medications?
No drug interactions are recorded for candyleaf in our sources. This does not rule them out — check with a pharmacist.
What are the common names of candyleaf?
candyleaf is also known as: Стевия медовая, stévia.
Is candyleaf a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Feature-Based Molecular Networking Approach for Exploring the Chemical Profile and Quantification of Polyphenols in Stevia rebaudiana, Bertoni Using HR-LC-ESI-Orbitrap-MSn. literature abstract metadata
- T2 Multi-omics dissection of steviol glycoside synthesis reveals haplotype-linked specialization of UGT76G genes in Stevia rebaudiana. literature abstract metadata
- T2 Stevioside extends the healthspan and improves Alzheimer's disease and increases oxidative stress resistance via the mitochondrial unfolded protein response. literature abstract metadata
- T2 Stevia extract alleviated spleen inflammatory injury in LPS-stressed mice by inhibiting the TLR4/MYD88/NF-κB signaling pathway. literature abstract metadata
- T2 Raman Spectroscopic Authentication of Rebaudioside M: Discriminating Natural, Fermentation-Derived, and Enzymatically Bioconverted Stevia Sweeteners. literature abstract metadata