Ashitaba
Angelica keiskei
Angelica keiskei is a plant traditionally used in Japanese medicine, particularly for its purported effects on digestion and female reproductive health. Scientific evidence suggests that 4-hydroxyderricin from Angelica keiskei may increase BRCA1 stability in triple-negative breast cancer cells by inhibiting cathepsin S, indicating potential anti-cancer properties. Additionally, it has shown neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway and enhancing laser-induced vasodilation in aortic rings through eNOS-dependent mechanisms, suggesting possible cardiovascular benefits. Angelica keiskei also demonstrated synergistic interaction with photobiomodulation and improved color values while reducing residual nitrite in cured pork loins. No major safety issues or drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that 4-hydroxyderricin from Angelica keiskei increased BRCA1 stability in triple-negative breast cancer cells through inhibition of cathepsin S.
- DMC treatment showed neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway.
- Angelica keiskei enhanced laser-induced vasodilation in aortic rings through eNOS-dependent mechanisms, showing synergistic interaction with photobiomodulation.
- Cured pork loins treated with pre-converted Angelica keiskei, ascorbic acid, and ultrasound showed similar color values but lower residual nitrite compared to traditional nitrite-cured loins.
Frequently asked questions
What is Ashitaba?
Ashitaba (Angelica keiskei) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Ashitaba?
4 sourced findings are recorded for Ashitaba; the strongest carries evidence grade D. For example: The study found that 4-hydroxyderricin from Angelica keiskei increased BRCA1 stability in triple-negative breast cancer cells through inhibition of cathepsin S.
How strong is the evidence for Ashitaba?
The strongest finding for Ashitaba carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Ashitaba safe? What are the side effects?
No major safety issues are recorded for Ashitaba in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Ashitaba interact with medications?
No drug interactions are recorded for Ashitaba in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Ashitaba?
Ashitaba is also known as: Дудник съедобный.
Is Ashitaba a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Enhancement of laser-induced vasodilation by medicinal plants: The eNOS-dependent and antioxidant actions of Panax ginseng and Angelica keiskei. literature abstract metadata
- T2 4,4'-dimethoxychalcone exerts neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway. literature abstract metadata
- T2 4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S. literature abstract metadata
- T2 Influence of Naturally Converted Nitrite and Ultrasound Marination on the Curing Efficiency and Residual Nitrite of Pork Loin. literature abstract metadata