Gigantic Angelica
Angelica gigas
Angelica gigas, a traditional plant used in Korean medicine, has not been documented for specific traditional uses. Scientific evidence suggests potential liver injury from this herb among others, though findings are supported by limited cellular and molecular validation. Decursin, a compound derived from Angelica gigas, shows promise in suppressing mast cell activation and reducing IgE-mediated anaphylactic responses in mice. Additionally, the combination of JI-CJ002 with dabrafenib demonstrates enhanced antitumor activity in melanoma by downregulating B7-H3 expression. No major safety concerns or recorded drug interactions have been identified to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study used UHPLC profiling and RWR network analysis to predict potential liver injury from Angelica gigas extracts, supported by cellular and molecular validation.
- The combination of JI-CJ002 with dabrafenib showed enhanced antitumor activity in melanoma by downregulating B7-H3 expression.
- Decursin suppresses mast cell activation and reduces IgE-mediated anaphylactic responses in mice.
- CGAC normalized the stagnant bone remodeling state and restored physiological remodeling in orchiectomy-induced mice, without explicit dose or treatment advice.
Frequently asked questions
What is Gigantic Angelica?
Gigantic Angelica (Angelica gigas) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Gigantic Angelica?
4 sourced findings are recorded for Gigantic Angelica; the strongest carries evidence grade D. For example: The study used UHPLC profiling and RWR network analysis to predict potential liver injury from Angelica gigas extracts, supported by cellular and molecular validation.
How strong is the evidence for Gigantic Angelica?
The strongest finding for Gigantic Angelica carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Gigantic Angelica safe? What are the side effects?
No major safety issues are recorded for Gigantic Angelica in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Gigantic Angelica interact with medications?
No drug interactions are recorded for Gigantic Angelica in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Gigantic Angelica?
Gigantic Angelica is also known as: Дудник гигантский, Angélique géante.
Is Gigantic Angelica a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Combining UHPLC profiling and random walk network-based in vitro analysis to predict herb-induced liver injury. literature abstract metadata
- T2 Decursin, a bioactive compound from Angelica gigas, suppresses mast cell activation by targeting Fyn kinase and attenuates IgE-mediated anaphylactic responses in mice. literature abstract metadata
- T2 JI-CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7-H3. literature abstract metadata
- T2 A Standard Herbal Formula, CGAC, Attenuates Bone Loss by Normalizing Low-Bone Turnover Stagnation in an Orchiectomy-Induced Mouse Model. literature abstract metadata