Angelica sachalinensis
Angelica sachalinensis
Angelica sachalinensis is a traditional medicine plant native to northeastern Asia. While its specific uses are not documented within traditional practices, it has been studied for various health benefits. Scientific evidence suggests that decursin, a compound found in Angelica sachalinensis, may alleviate colitis by inhibiting the cGAS-STING signaling pathway and restoring the intestinal mucosal barrier. Additionally, research indicates that certain derivatives of decursin exhibit antiproliferative activity against lung cancer cells, with (S)-2d being particularly potent. A meta-analysis found a significant increase in pregnancy rates with herbal medicine compared to placebo for treating female infertility; however, due to poor methodological quality, the findings should be interpreted cautiously. The most important safety caution is that no major issues have been recorded during clinical trials of HemoHIM, derived from Angelica sachalinensis roots, over an 8-week period in healthy adults. There are also no reported drug interactions associated with this plant.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The meta-analysis suggested a significant increase in pregnancy rates with herbal medicine compared to placebo for treating female infertility, though methodological quality was poor.
- Decursin treatment alleviated DSS-induced colitis by inhibiting the cGAS-STING signaling pathway and restoring the intestinal mucosal barrier.
- A series of decursin derivatives showed antiproliferative activity against A549 human lung cancer cells, with (S)-2d being the most potent.
- The study found that HemoHIM, derived from Angelica sachalinensis roots, showed no clinically significant safety concerns in healthy adults over 8 weeks.
Frequently asked questions
What is Angelica sachalinensis?
Angelica sachalinensis (Angelica sachalinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Angelica sachalinensis?
4 sourced findings are recorded for Angelica sachalinensis; the strongest carries evidence grade A. For example: The meta-analysis suggested a significant increase in pregnancy rates with herbal medicine compared to placebo for treating female infertility, though methodological quality was poor.
How strong is the evidence for Angelica sachalinensis?
The strongest finding for Angelica sachalinensis carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Angelica sachalinensis safe? What are the side effects?
No major safety issues are recorded for Angelica sachalinensis in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Angelica sachalinensis interact with medications?
No drug interactions are recorded for Angelica sachalinensis in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Angelica sachalinensis?
Angelica sachalinensis is also known as: Дудник сахалинский.
Is Angelica sachalinensis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Herbal therapeutics for female infertility: A systematic review and meta-analysis. literature abstract metadata
- T2 Synthesis, Antiproliferative Activity and Molecular Docking Analysis of Both Enantiomerically Pure Decursin Derivatives as Anticancer Agents. literature abstract metadata
- T2 Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway. literature abstract metadata
- T2 Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers. literature abstract metadata