FolkKB

Huachuca Skullcap

Scutellaria

Scutellaria, a genus of plants traditionally used in various Asian and Chinese medicine systems, has seen increasing scientific interest. The plant is traditionally utilized for its purported medicinal properties, although specific uses vary across different traditions. Scientific evidence suggests that Scutellaria barbata, one species within the genus, may have anti-cancer effects, particularly against colorectal cancer liver metastasis and breast cancer lung metastasis, through mechanisms such as ferroptosis induction and suppression of epithelial-mesenchymal transition (EMT). However, these findings are based on in vitro and in vivo studies and require further validation. No significant safety concerns or drug interactions have been reported for Scutellaria, though comprehensive clinical trials are still needed to fully understand its potential benefits and risks.

At a glance
Best evidence
B
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • HD-SB treatment reduced hepatic tumor nodules and suppressed epithelial-mesenchymal transition in both in vivo and in vitro models of colorectal cancer liver metastasis. D PMID
  • Scutellaria barbata water extract suppressed breast cancer growth and lung metastasis by inducing ferroptosis and inhibiting EMT, without causing systemic toxicity. D PMID
  • The study identified metabolite differences between two specifications and four geographical sources of Scutellaria baicalensis Georgi using machine learning. D PMID
  • The combined use of Hedyotis diffusa and Scutellaria barbata shows more pronounced effects against hepatocellular carcinoma than individual use, though further research is needed to confirm these findings. D PMID
  • The study successfully used SQPCA combined with 2T2D correlation spectroscopy to semi-quantitatively determine flavonoid concentrations in Scutellaria baicalensis roots. D PMID
  • The study found that use of Chinese herbal medicine was associated with a significantly higher 10-year overall survival rate compared to non-users among triple-negative breast cancer patients. B PMID
  • The study identified 25 SbGATA genes in Scutellaria baicalensis and found that SbGATA6 expression was upregulated by carbon dot treatment, while other genes showed downregulation. D PMID

Frequently asked questions

What is Huachuca Skullcap?

Huachuca Skullcap (Scutellaria) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Huachuca Skullcap?

7 sourced findings are recorded for Huachuca Skullcap; the strongest carries evidence grade B. For example: HD-SB treatment reduced hepatic tumor nodules and suppressed epithelial-mesenchymal transition in both in vivo and in vitro models of colorectal cancer liver metastasis.

How strong is the evidence for Huachuca Skullcap?

The strongest finding for Huachuca Skullcap carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Huachuca Skullcap safe? What are the side effects?

No major safety issues are recorded for Huachuca Skullcap in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Huachuca Skullcap interact with medications?

No drug interactions are recorded for Huachuca Skullcap in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Huachuca Skullcap?

Huachuca Skullcap is also known as: Шлемник, Scutellaire.

Is Huachuca Skullcap a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Integrative Chinese Herbal Medicine as Adjuvant Management for Triple-Negative Breast Cancer: A Multi-Institutional Real-World Study With Mechanism Exploration. literature abstract metadata
  2. T2 Scutellaria Barbata Water Extract Suppresses Breast Cancer Growth and Lung Metastasis by Inducing Ferroptosis. literature abstract metadata
  3. T2 Hedyotis diffusa Willd-Scutellaria barbata D.Don Suppresses Colorectal Cancer Liver Metastasis by Targeting hsa_circ_0039933-Mediated Epithelial-Mesenchymal Transition. literature abstract metadata
  4. T2 A Comprehensive Review of Hedyotis Diffusa Willd-Scutellaria Barbata D. Don Herb Pair in Anti- Hepatocellular Carcinoma Effects and Their Combinatorial Effects and Mechanisms. literature abstract metadata
  5. T2 Genome-Wide Identification and Expression Pattern Analysis of the GATA Gene Family Members in Scutellaria baicalensis Georgi Under Carbon Dot Treatment. literature abstract metadata
  6. T2 Metabolomics coupled with machine learning highlights metabolite profile differences of Scutellaria baicalensis Georgi from different specifications and geographical origins. literature abstract metadata
  7. T2 EXPRESS: Two-Trace Two-Dimensional (2T2D) Correlation Spectroscopy with Score-Based Quantitative Principal Component Analysis for the Quantification of Multicomponent Chemical Systems Using Attenuated Total Reflection Fourier Transform Infr literature abstract metadata

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